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Medchemexpress LLC AZ 11645373 | 227088-94-0 | 99.54% | 463.51 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1086701MG

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AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors. It inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells, with an IC50 value of 90 nM.

  • Highly selective and potent antagonist at human P2X7 receptors.
  • Inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells.
  • Produces a concentration-dependent inhibition of BzATP-mediated calcium transients.
  • No significant effect on basal levels of IL-1β in culture medium of LPS-treated cells at specified concentrations.

Catalog No. 50-003-46383


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