Apexbio Technology LLC AZ 628 878739-06-1 10mg

Supplier:  Apexbio Technology LLC A837110

AZ 628 (CAS 878739-06-1) is a potent inhibitor of RAF kinases targeting BRAF c-RAF-1 and the mutant BRAFV600E with reported IC50 values of 105 nM 34 nM and 29 nM respectively The compound exerts its activity by occupying the ATP-binding site of RAF kinases thereby blocking CRAF activation it also affects other tyrosine kinases such as DDR2 VEGFR2 Lyn Flt1 and FMS AZ 628 disrupts the RAS-RAF-MEK-ERK (MAPK) signaling cascade influencing cellular responses including proliferation and apoptosis In preclinical studies AZ 628 inhibits growth and induces apoptosis in BRAF V600E-mutant melanoma and colorectal cancer cell lines and demonstrates anti-angiogenic effects via VEGFR2 inhibition

Catalog No. 50-000-96016