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Medchemexpress LLC AZ10606120 dihydrochloride | 607378-18-7 | 99.9% | 495.48 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY10866910MG

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AZ10606120 dihydrochloride is a selective, high-affinity antagonist for the P2X7 receptor (P2X7R) in human and rat, with an IC50 of approximately 10 nM. It shows minimal to no effect on other P2XR subtypes. This compound demonstrates anti-depressant properties and has been observed to reduce tumor growth.

  • Selective, high-affinity antagonist for P2X7 receptor
  • Minimal cross-reactivity with other P2XR subtypes
  • Exhibits anti-depressant effects
  • Reduces tumor growth in various models
  • Depletes tumor cells in patient-derived glioblastoma samples
  • Increases lactate dehydrogenase levels in human glioblastoma cultures
  • Reduces proliferation, cell migration, and invasion in PDAC cell lines
  • Reverses streptozotocin-induced VEGF and IL-6 expression in rat retinae

Catalog No. 50-003-45966


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