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Medchemexpress LLC AZ10606120 dihydrochloride | 607378-18-7 | 99.93% | 495.48 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108669
AZ10606120 dihydrochloride is a selective, high affinity antagonist for the P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10 nM. It exhibits minimal or no effect at other P2XR subtypes and has demonstrated anti-depressant effects and the ability to reduce tumor growth.
- Selective and high-affinity antagonist for P2X7 receptor.
- Little or no effect on other P2XR subtypes.
- Shows anti-depressant effects.
- Reduces tumor growth.
- Depletes tumor cells in patient-derived primary glioblastoma samples.
- Increases Lactate dehydrogenase (LDH) levels in human primary glioblastoma cultures.
- Reduces proliferation, cell migration, and invasion in PDAC cell lines.
- Reverses Streptozotocin-induced VEGF and IL-6 expression in rat retinae.
- Exhibits antidepressant phenotype in LPS-induced anhedonia mice.
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