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AdipoGen AZ191
SDP

Supplier:  AdipoGen AGCR13657M005

Encompass_Preferred

Chemical. CAS 1594092-37-1. Formula C24H27N7O. MW 429.5. Synthetic. Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B IC50=17nM with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-Y-phosphorylation regulated kinase 1B DYRK1B belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.

Catalog No. 50-256-2249


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