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Apexbio Technology LLC AZ20 1233339-22-4 5mg
Supplier: Apexbio Technology LLC A32105
AZ20 (CAS 1233339-22-4) is a potent and selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase In biochemical assays AZ20 inhibits ATR with an IC50 of 5 nM in HeLa nuclear extracts and suppresses ATR-mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma cells with an IC50 of 50 nM The compound displays high selectivity for ATR over related kinases such as PI3K isoforms ATM and DNA-PK and minimal activity against mTOR In preclinical models AZ20 demonstrates significant inhibition of tumor growth in LoVo colorectal cancer xenografts following oral administration AZ20 serves as a valuable chemical probe for studying ATR function and the therapeutic potential of ATR inhibition in cancer research
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