Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 502240251

Apexbio Technology LLC AZ20 1233339-22-4 5mg
SDP

Catalog No. 502240251
Encompass_Preferred

AZ20 (CAS 1233339-22-4) is a potent and selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase In biochemical assays AZ20 inhibits ATR with an IC50 of 5 nM in HeLa nuclear extracts and suppresses ATR-mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma cells with an IC50 of 50 nM The compound displays high selectivity for ATR over related kinases such as PI3K isoforms ATM and DNA-PK and minimal activity against mTOR In preclinical models AZ20 demonstrates significant inhibition of tumor growth in LoVo colorectal cancer xenografts following oral administration AZ20 serves as a valuable chemical probe for studying ATR function and the therapeutic potential of ATR inhibition in cancer research

This item is not returnable. View return policy
Catalog No. 50-224-0251 Supplier Apexbio Technology LLC Supplier No. A32105
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

AZ20 (CAS 1233339-22-4) is a potent and selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase In biochemical assays AZ20 inhibits ATR with an IC50 of 5 nM in HeLa nuclear extracts and suppresses ATR-mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma cells with an IC50 of 50 nM The compound displays high selectivity for ATR over related kinases such as PI3K isoforms ATM and DNA-PK and minimal activity against mTOR In preclinical models AZ20 demonstrates significant inhibition of tumor growth in LoVo colorectal cancer xenografts following oral administration AZ20 serves as a valuable chemical probe for studying ATR function and the therapeutic potential of ATR inhibition in cancer research

This item is not returnable. View return policy
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.