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Apexbio Technology LLC AZD-3463 1356962-20-3 100mg
Supplier: Apexbio Technology LLC A8620100
AZD-3463 (CAS 1356962-20-3) is an orally bioavailable small molecule inhibitor targeting anaplastic lymphoma kinase (ALK) and insulin-like growth factor 1 receptor (IGF1R) exhibiting a Ki of 0 75 nM ALK expression is predominantly neuronal and is upregulated in neuroblastoma where its activation promotes cell survival and proliferation In vitro AZD-3463 suppresses proliferation of neuroblastoma cell lines with wild-type or mutant ALK by inhibiting the ALK-mediated PI3K/AKT/mTOR signaling pathway leading to apoptosis and autophagy induction AZD-3463 also enhances the cytotoxicity of chemotherapeutic agents such as doxorubicin and temozolomide In vivo it has demonstrated efficacy in reducing neuroblastoma growth in xenograft mouse models
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