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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 25mg, CAS: 1869912-39-9.
Supplier: Apexbio Technology LLC C307625
AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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