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Apexbio Technology LLC AZD-5597 924641-59-8 25mg
Supplier: Apexbio Technology LLC B592625
AZD-5597 (CAS 924641-59-8) is an imidazole pyrimidine amide compound that acts as a potent inhibitor of cyclin-dependent kinases CDK1 and CDK2 exhibiting an IC50 of 2 nM for both enzymes CDKs are serine/threonine protein kinases involved in regulation of the cell cycle transcription mRNA processing and neuronal differentiation In cellular studies AZD-5597 demonstrates strong antiproliferative activity such as an MIC50 of 0 039 M in LoVo cells The compound displays high aqueous solubility stability under various conditions and does not inhibit CYP enzymes Preclinical pharmacokinetic evaluations reveal favorable properties supporting its utility as a research tool for investigating CDK inhibition and antitumor activity
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