Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 502562216

AdipoGen AZD 7545
SDP

Supplier:  AdipoGen AGCR13692M001

Encompass_Preferred

Chemical. CAS 252017-04-2. Formula C19H18ClF3N2O5S. MW 478.9. . Potent and selective pyruvate dehydrogenase kinase 2 PDK2 inhibitor IC50=6.4nM, consequently increasing pyruvate dehydrogenase PDH activity. Less potent inhibitor towards PDK1 and PDK3 IC50=87 and 600nM, respectively. Inhibitor of glycolysis. Antiobesity and antidiabetic agent. Improves blood glucose control in obese fa/fa Zucker rats. Useful agent for immunometabolism research. To maintain a continuous and steady supply of ATP during the feed-fast cycle, cells must select fatty acid or glucose for fuel. This process is largely controlled by the pyruvate dehydrogenase complex PDC, which regulates the entry of glycolytic products into the tricarboxylic acid cycle by catalyzing the oxidative decarboxylation of pyruvate to acetyl-coenzyme A CoA in the mitochondria of mammalian cells.

Catalog No. 50-256-2216


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.