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Medchemexpress LLC Azd-7762 hydrochloride | 1246094-78-9 | 99.58% | 398.88 | 25 MG
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Catalog No. 5000347572
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AZD-7762 hydrochloride is a potent ATP-competitive checkpoint kinase (Chk) inhibitor with an IC50 of 5 nM for Chk1. It inhibits Chk1 and Chk2, abrogates DNA damage-induced S and G2 checkpoints, enhances the efficacy of NSC 613327 and SKF 104864A, and modulates downstream checkpoint pathway proteins. It potentiates antitumor activity and induces lymphoma cell death in combination with CX-5461.

  • Potent ATP-competitive checkpoint kinase (Chk) inhibitor.
  • IC50 of 5 nM for Chk1.
  • Equally potent inhibitor of Chk1 and Chk2 in vitro.
  • Abrogates DNA damage-induced S and G2 checkpoints.
  • Enhances the efficacy of NSC 613327 and SKF 104864A.
  • Modulates downstream checkpoint pathway proteins.
  • Binds to the ATP-binding site of Chk1.
  • Potentiates antitumor activity in xenograft studies.
  • Induces lymphoma cell death in combination with CX-5461.

Catalog No. 50-003-47572 Supplier Medchemexpress LLC Supplier No. 25MGHY10992A
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AZD-7762 hydrochloride is a potent ATP-competitive checkpoint kinase (Chk) inhibitor with an IC50 of 5 nM for Chk1. It inhibits Chk1 and Chk2, abrogates DNA damage-induced S and G2 checkpoints, enhances the efficacy of NSC 613327 and SKF 104864A, and modulates downstream checkpoint pathway proteins. It potentiates antitumor activity and induces lymphoma cell death in combination with CX-5461.

  • Potent ATP-competitive checkpoint kinase (Chk) inhibitor.
  • IC50 of 5 nM for Chk1.
  • Equally potent inhibitor of Chk1 and Chk2 in vitro.
  • Abrogates DNA damage-induced S and G2 checkpoints.
  • Enhances the efficacy of NSC 613327 and SKF 104864A.
  • Modulates downstream checkpoint pathway proteins.
  • Binds to the ATP-binding site of Chk1.
  • Potentiates antitumor activity in xenograft studies.
  • Induces lymphoma cell death in combination with CX-5461.

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