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Apexbio Technology LLC AZD1208 1204144-28-4 200mg
Supplier: Apexbio Technology LLC A3962200
AZD1208 (CAS 1204144-28-4) is a selective orally bioavailable pan-Pim kinase inhibitor targeting Pim-1 Pim-2 and Pim-3 kinases with IC50 values of 0 4 nM 5 nM and 1 9 nM respectively Pim kinases are implicated in proliferative and anti-apoptotic signaling downstream of cytokines and growth factors frequently overexpressed in leukemia and lymphoma In vitro AZD1208 inhibits growth induces cell cycle arrest apoptosis and reduces phosphorylation of the anti-apoptotic protein Bcl-2 in AML cell lines Preclinically this compound suppresses tumor growth in AML xenograft models supporting its current clinical evaluation in AML and solid tumor trials
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