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AdipoGen AZD1208 (5 mg)
Supplier: AdipoGen SYN1214M005
AZD1208 (5 mg), AdipoGen Life Sciences. Chemical. CAS: 1204144-28-4. Formula: C21H21N3O2S. MW: 379.5. Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nM or <150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
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