Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 1 ML

Supplier:  Medchemexpress LLC HY110346100MG

AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15 nM, 21 nM, and 15 nM, respectively, and induces apoptosis. It inhibits cell viability in cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells. It also downregulates cIAP-1, activates RIPK1 (upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7.

• Antagonist of inhibitor of apoptosis proteins (IAPs).
• Binds to BIR3 domains of cIAP1, cIAP2, and XIAP.
• Induces apoptosis.
• Inhibits cell viability in NSCLC cells.
• Downregulates cIAP-1 and activates RIPK1.
• Triggers extrinsic and intrinsic apoptosis pathways.

Catalog No. 50-003-43402