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Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG
Supplier: Medchemexpress LLC HY11034610MG
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), binding to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis and is for research use only.
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells
- Downregulates cIAP-1 and activates RIPK1
- Triggers extrinsic and intrinsic apoptosis pathways
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in vivo
- Leads to substantial tumor regressions in xenograft models
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