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Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.9% | 1088.21 | 25 MG
Supplier: Medchemexpress LLC 25MGHY110346
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively, and induces apoptosis.
- Antagonist of inhibitor of apoptosis proteins (IAPs)
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells in cooperation with IFNγ or viral double-stranded RNA (dsRNA)
- Downregulates cIAP-1, activates RIPK1, and triggers activation of extrinsic and intrinsic apoptosis pathways in H1975 NSCLC cells
- Involves in apoptosis in HCC827 NSCLC cells due to induction of cell death and active caspase-3/8 activities by AZD5582 and IFNγ co-treatment
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in MDA-MB-231 xenograft-bearing mice
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