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Apexbio Technology LLC AZD6482 1173900-33-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A54785.1
AZD6482 (CAS 1173900-33-8) is a selective ATP-competitive inhibitor of phosphoinositide 3-kinase beta (PI3K ) It exhibits inhibitory potency with IC50 values of 0 69 nM for PI3K compared to 13 6 nM for PI3K 47 8 nM for PI3K and 136 nM for PI3K In vitro AZD6482 reduces insulin-induced glucose uptake in human adipocytes (IC50 of 4 4 M) Preclinical studies in dogs indicate anti-thrombotic activity without elevating bleeding risks Clinical evaluation showed good tolerability in human volunteers with modest effects on insulin sensitivity parameters AZD6482 serves as a valuable tool to investigate PI3K function in platelet biology and metabolic regulation
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