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Medchemexpress LLC Azd8848 | 866269-28-5 | 99.1% | 569.70 | 50 MG
Supplier: Medchemexpress LLC HY11126950MG
AZD8848 is a selective toll-like receptor 7 (TLR7) anteagent agonist. It shows good activity against TLR7, with cellular pEC50s of 7.0 for human TLR7 and 6.6 for rat TLR7. It has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5. AZD8848 is a potent, selective TLR7 agonist antedrug able to inhibit Th2 responses in vitro and has no activity against human TLR8 or any other human TLRs. In vivo, it has good pharmacokinetics in the Brown Norway rat and suppresses ovalbumin (OVA) challenge in the rat allergy model.
- Developed for the research of asthma and allergic rhinitis
- Selective TLR7 agonist
- Inhibits Th2 responses in vitro
- No activity against human TLR8 or other human TLRs
- Suppresses ovalbumin (OVA) challenge in the rat allergy model
- Appears as a white to off-white solid
- Soluble in DMSO
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