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Apexbio Technology LLC AZD8931 (Sapitinib) 848942-61-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A83755.1
AZD8931 (Sapitinib CAS 848942-61-0) is a reversible small-molecule inhibitor that targets EGFR (HER1) HER2 (erbB2) and HER3 (erbB3) with similar potency It suppresses receptor phosphorylation with IC50 values of 4 nM (EGFR) 3 nM (HER2) and 4 nM (HER3) Preclinical studies using HER2-non-amplified inflammatory breast cancer (IBC) cell lines demonstrate reduced tumor cell proliferation and increased apoptosis upon AZD8931 administration In mouse xenograft models AZD8931 alone or combined with paclitaxel significantly delays tumor growth AZD8931 is under clinical evaluation as combination therapy in advanced breast cancer
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