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Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | 98.2% | 455.46 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY19427A50MG

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AZD9056 hydrochloride is a selective orally active inhibitor of P2X7, which plays a significant role in inflammation and pain-causing diseases. It is for research use only and not sold to patients.

  • Selective orally active inhibitor of P2X7.
  • Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
  • Exhibits high selectivity for the P2X7 receptor.
  • Has an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
  • Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
  • Exerts pain-relieving and anti-inflammatory effects in vivo.
  • Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.

Catalog No. 50-003-84932


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