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Medchemexpress LLC AZD9496 | 1639042-08-2 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12870A10MG

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AZD9496 is an orally active, selective estrogen receptor degrader (SERD) and an effective, selective estrogen receptor (ERα) antagonist. It demonstrates high potency with an IC50 of 0.28 nM for ERα antagonism and significantly inhibits MCF-7 cell growth.

  • Orally active, selective estrogen receptor degrader (SERD)
  • Effective and selective estrogen receptor (ERα) antagonist
  • IC50 of 0.28 nM for ERα antagonism
  • Inhibits MCF-7 cell growth with an EC50 of 0.04 nM
  • High selectivity over other nuclear hormone receptors
  • Shows significant tumor growth inhibition in estrogen-dependent MCF-7 xenograft models
  • Leads to further growth-inhibitory effects when combined with PI3K pathway and CDK4/6 inhibitors
  • Demonstrates significant activity in long-term estrogen-deprived models

Catalog No. 50-003-42534


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