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Medchemexpress LLC Azido-PEG1-NHS ester | 1807530-06-8 | 99.78% | C9H12N4O5 | 25 MG
Supplier: Medchemexpress LLC 25MGHY140756
Azido-PEG1-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It serves as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits the intracellular ubiquitin-proteasome system
- Selective degradation of target proteins
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