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Medchemexpress LLC Azido-PEG16-NHS ester | 2553413-74-2 | 99.9% | C39H72N4O20 | 25 MG
Supplier: Medchemexpress LLC 25MGHY140761
Azido-PEG16-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups. It also engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This compound supports the PROTACs mechanism, which involves two ligands connected by a linker, allowing selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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