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Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 25 MG
Supplier: Medchemexpress LLC 25MGHY141249
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein, and they degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an Azide group for CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups
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