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Medchemexpress LLC Azido-PEG6-alcohol | 86770-69-6 | 98.0% | 250 MG
Supplier: Medchemexpress LLC 250MGHY130537
Azido-PEG6-alcohol is a PEG-based PROTAC linker designed for the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). It acts as a click chemistry reagent, featuring an Azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This compound facilitates the degradation of target proteins through the intracellular ubiquitin-proteasome system via PROTACs, and links cytotoxins to antibodies through ADCs.
- Functions as a PEG-based PROTAC linker
- Suitable for synthesizing PROTACs and ADCs
- Contains an Azide group for click chemistry reactions
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Facilitates protein degradation via PROTACs
- Enables conjugation of cytotoxins in ADCs
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