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Medchemexpress LLC Azido-PEG8-hydrazide | 2353410-11-2 | 96.1% | C19H39N5O9 | 25 MG
Supplier: Medchemexpress LLC 25MGHY140815
Azido-PEG8-hydrazide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs, which are composed of two different ligands connected by a linker, leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Functions as a click chemistry reagent
- Contains an azide group for CuAAc reactions
- Participates in SPAAC reactions
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins via the ubiquitin-proteasome system
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