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Cayman Chemical AzIdo-ThalIdomIde 5mg

Supplier: Cayman Chemical 261465 MG

An orally bioavailable helicase-primase inhibitor inhibits the ATPase activity of HSV helicase-primase (IC50 30 nM) inhibits HSV replication in Vero cells (IC50 20 nM for both HSV-1 and HSV-2) active against porcine and bovine HSV strains (IC50s 5 and 0.12 M respectively) effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 0.5 mg/kg in mice and rats) and in a zosteriform spread model at a dose of 15 mg/kg in mice and Lewis rats reduces levels of AB and phosphorylated Tau production in HSV-1 infected Vero cells
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