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Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 10 MG
Supplier: Medchemexpress LLC HYP023110MG
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. It exerts survival effects on pancreatic b-cells and human pancreatic islets comparable to unacylated ghrelin (UAG). It is very stable in human plasma in vitro with no degradation observed after 1 day of incubation at 37°C.
- Prevents body weight increase caused by a high-fat diet in mice
- Prevents high-fat diet-induced proinflammatory effects
- Stimulates mitochondrial function markers in brown adipose tissue
- Prevents the development of a prediabetic metabolic state
- Prevents a high-fat diet-induced increase in acyl ghrelin levels
- Significantly improves glucose concentrations without increasing insulin levels
- Decreases mean body weight by 2.6 kg (vs 0.8 kg for placebo)
- Reduces HbA1c by 0.4% (vs 0.2% for placebo)
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