Medchemexpress LLC Aztreonam | 78110-38-0 | 99.6% | 1 ML

Supplier:  Medchemexpress LLC HYB012910MM/1ML

Aztreonam is a synthetic monocyclic beta-lactam antibiotic with a high affinity for penicillin-binding protein 3 (PBP-3). It was approved by the U.S. Food and Drug Administration in 1986. This antibiotic is resistant to some beta-lactamases but can be inactivated by extended-spectrum beta-lactamases. It shows no useful activity against gram-positive or anaerobic microorganisms. Aztreonam inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a mild affinity for PBP-1a and is largely ineffective against gram-positive and anaerobic bacteria due to poor binding to their penicillin-binding proteins. Aztreonam is bactericidal, though less so than some cephalosporins.

• Synthetic monocyclic beta-lactam antibiotic
• High affinity for penicillin-binding protein 3 (PBP-3)
• Resistant to some beta-lactamases
• Inhibits mucopeptide synthesis in the bacterial cell wall
• Bactericidal

Catalog No. 50-004-50686