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Apexbio Technology LLC B-Raf inhibitor 1 dihydrochloride 1191385-19-9 100mg
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Catalog No. 5000088318
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B-Raf inhibitor 1 dihydrochloride (CAS 1191385-19-9) is a small molecule inhibitor targeting B-Raf kinase including both wild-type and mutant forms such as the V600E variant commonly found in tumor cells As a type IIA inhibitor it binds to the DFG-out conformation of the ATP-binding site on B-Raf The compound demonstrates inhibitory activity against cell proliferation with IC50 values of 0 31 M in A375 cells and 0 72 M in HCT116 cells B-Raf inhibitor 1 also inhibits other tyrosine kinases and in cells expressing wild-type B-Raf can promote activation of the RAF-MEK-ERK signaling pathway through Raf dimerization In preclinical mouse models it has been observed to induce proliferation supporting its use in studies of Raf signaling kinase inhibitor specificity and oncogenic pathway modulation

Catalog No. 50-000-88318 Supplier Apexbio Technology LLC Supplier No. B1173100
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B-Raf inhibitor 1 dihydrochloride (CAS 1191385-19-9) is a small molecule inhibitor targeting B-Raf kinase including both wild-type and mutant forms such as the V600E variant commonly found in tumor cells As a type IIA inhibitor it binds to the DFG-out conformation of the ATP-binding site on B-Raf The compound demonstrates inhibitory activity against cell proliferation with IC50 values of 0 31 M in A375 cells and 0 72 M in HCT116 cells B-Raf inhibitor 1 also inhibits other tyrosine kinases and in cells expressing wild-type B-Raf can promote activation of the RAF-MEK-ERK signaling pathway through Raf dimerization In preclinical mouse models it has been observed to induce proliferation supporting its use in studies of Raf signaling kinase inhibitor specificity and oncogenic pathway modulation

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