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AdipoGen BAFF, Soluble (human) (60-mer) (rec.) (highly active)
Supplier: AdipoGen AG40B0112C010
BAFF, Soluble (human) (60-mer) (rec.) (highly active), AdipoGen Life Sciences. Protein. The extracellular domain of human BAFF (aa 134-285) is fused at the N-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.01EU/?g purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse BAFF-R, TACI and BCMA. Relative binding affinity (EC50) for BAFF-R (human): ~3ng/ml. Purity: >95% (SDS-PAGE). BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R.
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