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AdipoGen BAFF, Soluble (mouse) (rec.),Protein. Mouse BAFF
Supplier: AdipoGen AG40B0022C010
BAFF, Soluble (mouse) (rec.), AdipoGen Life Sciences. Protein. Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG?-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/?g purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse BAFF-R, TACI and BCMA. Purity: >90% (SDS-PAGE). BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells.
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