Thermo Scientific Chemicals Bafilomycin A1, 95%

Description

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
• It is a macrolide antibiotic, and shows fungicide activity

Application

• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
• It can be immunosuppressive
• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)

Specifications

Chemical Identifiers

• CAS: 88899-55-2
• Molecular Formula: C35H58O9
• Molecular Weight (g/mol): 622.84
• MDL Number: MFCD06795130
• InChI Key: XDHNQDDQEHDUTM-XRCNURIOSA-N
• PubChem CID: 133268469
• IUPAC Name: (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
• SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C

• Type: Bafilomycin A1
• Physical Form: Powder/Solid
• Color: White
• Quantity: 0.1 mg
• Assay Percent Range: 95%
• Solubility Information: Solubility in water: practically insoluble. Other solubilities: soluble in methanol, ethanol, dmso
• Formula Weight: 622.8
• Percent Purity: 95%
• Chemical Name or Material: Bafilomycin A1, 95%

Safety and Handling

Hazard Statement

GHS H Statement: May cause respiratory irritation. Causes serious eye irritation. Causes skin irritation.

Precautionary Statement

GHS P Statement: Avoid breathing dust/fume/gas/mist/vapors/spray. IF ON SKIN: Wash with plenty of soap and water. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

SDS

RUO – Research Use Only