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AdipoGen Bafilomycin A1 high purity
Supplier: AdipoGen AGCN22001C100
Chemical. CAS 88899-55-2. Formula C35H58O9. MW 622.8. Bafilomycin A1, a macrolide antibiotic, is a highly potent, selective inhibitor of vacuolar H-ATPases. Bafilomycin A1 is a potent inhibitor of cellular autophagy either by blocking autophagosome-lysosome fusion or by blocking lysosomal degradation. Bafilomycin A1 has several other biological properties. It induces apoptosis or acts as an ionophore, meaning it can transfer K ions across biological membranes. Bafilomycin A1 can induce mitochondrial swelling in the presence of K ions, stimulate the oxidation of pyrimidine nucleotides and uncouple oxidative phosphorylation. Inhibition of V-ATPase activity with bafilomycin A1 led to the exacerbation of NLRP3 inflammasome activation in human monocytes in response to LPS. Bafilomycin A1 also significantly inhibited SARS-CoV-2 replication. In cancer, bafilomycin A1 has been shown to inhibit the growth of tumor cells by blocking the acidification of lysosomes.
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