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Apexbio Technology LLC Balicatib 354813-19-7 10mg
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Catalog No. 5000092476
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Balicatib (CAS 354813-19-7) is a potent inhibitor of cathepsin K exhibiting an IC50 of 1 4 nM in enzymatic assays It demonstrates high selectivity for cathepsin K over closely related cathepsins such as B L and S in vitro though this selectivity is diminished in cell-based contexts due to lysosomal accumulation and subsequent off-target effects These off-target actions have been associated with cutaneous adverse events Developed for osteoporosis research balicatib has been shown to reduce biochemical markers of bone resorption and increase bone mineral density in ovariectomized primate models and display beneficial effects on bone formation in postmenopausal women

Catalog No. 50-000-92476 Supplier Apexbio Technology LLC Supplier No. B326510
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Balicatib (CAS 354813-19-7) is a potent inhibitor of cathepsin K exhibiting an IC50 of 1 4 nM in enzymatic assays It demonstrates high selectivity for cathepsin K over closely related cathepsins such as B L and S in vitro though this selectivity is diminished in cell-based contexts due to lysosomal accumulation and subsequent off-target effects These off-target actions have been associated with cutaneous adverse events Developed for osteoporosis research balicatib has been shown to reduce biochemical markers of bone resorption and increase bone mineral density in ovariectomized primate models and display beneficial effects on bone formation in postmenopausal women

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