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Medchemexpress LLC BAM(8-22) | 412961-36-5 | 99.89% | 1971.20 | 5 MG
Supplier: Medchemexpress LLC HYP12415MG
BAM(8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), specifically MrgprC11 and hMrgprX1. It induces scratching in mice in an Mrgpr-dependent manner. Additionally, BAM(8-22) has an analgesic effect and can inhibit the activation of microglia.
- Potent activator of Mas-related G-protein-coupled receptors (Mrgprs).
- Induces scratching in mice in an Mrgpr-dependent manner.
- Has an analgesic effect.
- Inhibits the activation of microglia.
- Increases miR-184 level in LPS-treated BV-2 cells.
- Reduces Iba-1 and inflammatory cytokines in LPS-treated BV-2 cells.
- Diminishes NMDA-evoked nocifensive behaviors and hyperalgesia in rat pain models.
- Reduces NMDA-evoked expression of FLI and NADPH reactivity in the spinal dorsal horn.
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