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Apexbio Technology LLC Bardoxolone methyl 218600-53-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A32215.1
Bardoxolone methyl (CAS 218600-53-4) is a synthetic oleanane triterpenoid that activates the KEAP1-Nrf2 signaling pathway and inhibits the NF- B-mediated inflammation It functions by stabilizing and activating the transcription factor Nrf2 which controls genes involved in cellular antioxidative responses detoxification and oxidative stress management In vitro bardoxolone methyl exhibits an IC50 of 1 5 nM toward NF- B inhibition This compound increases renal expression of Nrf2-regulated genes including HO-1 and NQO1 thereby protecting against aristolochic acid-induced acute kidney injury in animal models Bardoxolone methyl has research relevance as a tool for studying oxidative stress and inflammatory pathways associated with kidney injury and chronic kidney disease (CKD)
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