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Cayman Chemical BarIcItInIb 100mg
Supplier: Cayman Chemical 16707100 MG
A JAK1 and JAK2 inhibitor (IC50s = 0.0059 and 0.0057 µM, respectively); selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and Chk2 (IC50s = >0.4, 0.053, >10, and >1 µM, respectively); inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s = 0.044 and 0.128 µM, respectively); reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg; decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
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