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Medchemexpress LLC Baricitinib phosphate | 1187595-84-1 | C16H20N7O6PS | 5 MG
Supplier: Medchemexpress LLC HY15315A5MG
Baricitinib phosphate is a selective, orally bioavailable JAK1/JAK2 inhibitor with IC50 values of 5.9 nM and 5.7 nM, respectively. It is intended for research use only.
- Selective orally bioavailable JAK1/JAK2 inhibitor.
- Potent inhibitor of JAK signaling and function in cell-based assays.
- Inhibits IL-6-stimulated STAT3 phosphorylation and MCP-1 production in PBMCs.
- Inhibits IL-23-stimulated pSTAT3 in naive T-cells, preventing IL-17 and IL-22 production.
- Demonstrates in vivo efficacy in reducing inflammation and paw swelling.
- Reduces CD8 infiltration and MHC class I and class II expression in animal models.
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