Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000060482

Apexbio Technology LLC Baricitinib phosphate(Synonyms: Baricitinib phosphate, Olumiant phosphate, LY3009104 phosphate, INCB028050 phosphate), 200mg, CAS: 1187595-84-1.
SDP

Catalog No. 5000060482
Encompass_Preferred

Baricitinib phosphate (CAS 1187595-84-1) known as INCB028050 is an orally bioavailable small molecule inhibitor targeting Janus kinases JAK1 and JAK2 It selectively inhibits JAK1 and JAK2 with IC50 values of approximately 5 9 nM and 5 7 nM respectively exhibiting roughly 10-fold lower potency towards JAK3 and Tyk2 and lacking inhibition against c-Met and Chk2 By suppressing JAK1/2-mediated signaling baricitinib phosphate reduces signal transduction induced by proinflammatory cytokines such as IL-6 and IL-23 in vitro Preclinical studies in rodent arthritis models indicate notable therapeutic activity with minimal evidence of adverse hematological or immunosuppressive effects This compound is used widely in biomedical research for investigating inflammatory pathways in autoimmune disease models

Catalog No. 50-000-60482 Supplier Apexbio Technology LLC Supplier No. A3222200
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

Baricitinib phosphate (CAS 1187595-84-1) known as INCB028050 is an orally bioavailable small molecule inhibitor targeting Janus kinases JAK1 and JAK2 It selectively inhibits JAK1 and JAK2 with IC50 values of approximately 5 9 nM and 5 7 nM respectively exhibiting roughly 10-fold lower potency towards JAK3 and Tyk2 and lacking inhibition against c-Met and Chk2 By suppressing JAK1/2-mediated signaling baricitinib phosphate reduces signal transduction induced by proinflammatory cytokines such as IL-6 and IL-23 in vitro Preclinical studies in rodent arthritis models indicate notable therapeutic activity with minimal evidence of adverse hematological or immunosuppressive effects This compound is used widely in biomedical research for investigating inflammatory pathways in autoimmune disease models

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.