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Enzo Life Sciences BAY 11-7085 (10mg). CAS: 196309-76-9
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Supplier:  Enzo Life Sciences BMLEI2790010

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An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model. Purity: ≥99% (TLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Insoluble in water. Long Term Storage: Ambient.

Catalog No. 50-201-0661


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