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Apexbio Technology LLC Bay 11-7821 (BAY 11-7082)(Synonyms: BAY 11-7082, BAY-11-7082, BAY 117082, BAY11-7082, NF-kappaB inhibitor BAY 11-7082), 100mg, CAS: 19542-67-7.
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Catalog No. 5000060800
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Bay 11-7821 (also known as BAY 11-7082 CAS 19542-67-7) is a selective inhibitor of I B kinase (IKK) exhibiting an IC50 of 10 M It suppresses TNF -mediated phosphorylation of I B- thereby blocking NF- B activation and subsequent expression of adhesion molecules including E-selectin VCAM-1 and ICAM-1 Independent of NF- B inhibition Bay 11-7821 can induce cell death in B-cell lymphoma and leukemic T cells and suppresses the NALP3 inflammasome activation in macrophages Thus it serves as an important tool for studies on inflammatory signaling pathways and apoptosis regulation

Catalog No. 50-000-60800 Supplier Apexbio Technology LLC Supplier No. A4210100
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Bay 11-7821 (also known as BAY 11-7082 CAS 19542-67-7) is a selective inhibitor of I B kinase (IKK) exhibiting an IC50 of 10 M It suppresses TNF -mediated phosphorylation of I B- thereby blocking NF- B activation and subsequent expression of adhesion molecules including E-selectin VCAM-1 and ICAM-1 Independent of NF- B inhibition Bay 11-7821 can induce cell death in B-cell lymphoma and leukemic T cells and suppresses the NALP3 inflammasome activation in macrophages Thus it serves as an important tool for studies on inflammatory signaling pathways and apoptosis regulation

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