Medchemexpress LLC BAY-3827 | 2377576-35-5 | 99.7% | 468.53 | 1 ML

Supplier:  Medchemexpress LLC HY11208310MM/1ML

BAY-3827 is a chemical probe and a potent, selective AMPK inhibitor. It prevents phosphorylation of acetyl-CoA carboxylase 1 and exhibits strong anti-proliferative activity in androgen-dependent prostate cancer cell lines. This compound demonstrates high selectivity for kinases, with IC50 values of 1.4 nM at low (10 μM ATP) and 15 nM at high (2 mM ATP) concentrations.

• Potent and selective AMPK inhibitor.
• Exhibits strong anti-proliferative activity in androgen-dependent prostate cancer cell lines.
• Prevents phosphorylation of acetyl-CoA carboxylase 1.
• Shows over 500-fold selectivity for most of 331 kinases.
• IC50 values of 1.4 nM (10 μM ATP) and 15 nM (2 mM ATP).

Catalog No. 50-004-36156