Medchemexpress LLC BAY-3827 | 2377576-35-5 | 99.7% | 468.53 | 10 MG

Supplier:  Medchemexpress LLC HY11208310MG

BAY-3827 is a chemical probe that functions as a potent and selective AMPK inhibitor. It has IC50 values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). This compound exhibits over 500-fold selectivity for most of the 331 kinases tested. BAY-3827 prevents the phosphorylation of acetyl-CoA carboxylase 1 and demonstrates the strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines.

• Potent and selective AMPK inhibitor.
• IC50 values: 1.4 nM (10 μM ATP) and 15 nM (2 mM ATP).
• Over 500-fold selectivity across kinases.
• Prevents phosphorylation of acetyl-CoA carboxylase 1.
• Exhibits anti-proliferative activity in androgen-dependent prostate cancer cell lines.

Catalog No. 50-004-36048