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Medchemexpress LLC BAY-3827 | 2377576-35-5 | 99.7% | 468.53 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112083
BAY-3827 is a chemical probe and a potent, selective AMPK inhibitor. It exhibits high selectivity across kinases and prevents phosphorylation of acetyl-CoA carboxylase 1. This compound shows strong anti-proliferative activity in androgen-dependent prostate cancer cell lines.
- Potent and selective AMPK inhibitor.
- Inhibits AMPK with IC50 values of 1.4 nM (10 µM ATP) and 15 nM (2 mM ATP).
- Over 500-fold selectivity for most of 331 kinases.
- Reduces ACC1 Ser79 phosphorylation in LNCaP and VCaP cells.
- Represses LIPE gene expression and reduces AKT3 in VCaP cells.
- Increases lipid droplet formation in VCaP cells.
- Available in solid form, white to off-white appearance.
- Shows strong efficacy in androgen-dependent prostate cancer models.
- Inhibits proliferation of LNCaP, VCaP, and 22Rv1 cells.
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