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Medchemexpress LLC Bay-3827 | 2377576-35-5 | 99.72% | 468.53 | 50 MG
Supplier: Medchemexpress LLC HY11208350MG
BAY-3827 is a chemical probe that functions as a potent and selective AMPK inhibitor. It exhibits IC50 values of 1.4 nM at low ATP concentration (10 μM) and 15 nM at high ATP concentration (2 mM). This compound shows over 500-fold selectivity for most of the 331 kinases, preventing phosphorylation of acetyl-CoA carboxylase 1 and demonstrating significant anti-proliferative activity in androgen-dependent prostate cancer cell lines.
- Potent and selective AMPK inhibitor
- Shows over 500-fold selectivity for most of 331 kinases
- Prevents phosphorylation of acetyl-CoA carboxylase 1
- Demonstrates anti-proliferative activity in androgen-dependent prostate cancer cell lines
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