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Apexbio Technology LLC BAY 61-3606 732983-37-8 10mg
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Supplier:  Apexbio Technology LLC A322710

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BAY 61-3606 (CAS 732983-37-8) is a selective orally bioavailable inhibitor of spleen tyrosine kinase (SYK) displaying an IC50 of 10 nM and a Ki of 7 5 nM for SYK by competitively binding ATP This compound shows minimal activity against other tyrosine kinases such as Src Fyn Lyn Btk and Itk at concentrations up to 4 7 M BAY 61-3606 suppresses Fc RI-mediated degranulation and mediator release in mast cells and basophils as well as Fc R-driven responses in macrophages and neutrophils In preclinical models BAY 61-3606 attenuates inflammatory cell functions and reduces allergic and asthmatic responses supporting its utility in investigating SYK-mediated signaling and inflammation

Catalog No. 50-000-95796


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