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Medchemexpress LLC Bay 61-3606 hydrochloride | 1615197-10-8 | 98.08% | C20H19ClN6O3 | 5 MG
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Supplier:  Medchemexpress LLC HY76474A5MG

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BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and induces a large decrease of Syk phosphorylation in K-rn cell lysates. This compound also sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

  • Orally available
  • ATP-competitive and reversible
  • Highly selective Syk inhibitor
  • Reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells
  • Induces a large decrease of Syk phosphorylation in K-rn cell lysates
  • Sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells

Catalog No. 50-004-34524


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