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Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 1 ML
SDP

Catalog No. 5000345553
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BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. It has been nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). It demonstrates significant efficacy in preclinical models of ALI and lung emphysema, showing anti-inflammatory and anti-remodeling actions. Additionally, it has shown beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.

  • Orally bioavailable and cell-permeable inhibitor of human neutrophil elastase
  • Exhibits more than 2,000-fold selectivity in a panel of 21 serine proteases
  • Shows significant efficacy in preclinical models of ALI and lung emphysema
  • Demonstrates anti-inflammatory and anti-remodeling modes of action
  • Beneficial pulmonary hemodynamic and vascular effects in models of PAH

Catalog No. 50-003-45553 Supplier Medchemexpress LLC Supplier No. HY111457A100MG
May include imposed supplier surcharges.
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BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. It has been nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). It demonstrates significant efficacy in preclinical models of ALI and lung emphysema, showing anti-inflammatory and anti-remodeling actions. Additionally, it has shown beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.

  • Orally bioavailable and cell-permeable inhibitor of human neutrophil elastase
  • Exhibits more than 2,000-fold selectivity in a panel of 21 serine proteases
  • Shows significant efficacy in preclinical models of ALI and lung emphysema
  • Demonstrates anti-inflammatory and anti-remodeling modes of action
  • Beneficial pulmonary hemodynamic and vascular effects in models of PAH

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