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Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY111457A50MG

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BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

  • Orally bioavailable.
  • Highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE).
  • IC50 of 20 nM for HNE.
  • Nominated as a chemical probe via the Structural Genomics Consortium (SGC).
  • Ki value for MNE is 700 nM.
  • 4th generation inhibitor of HNE.
  • More than 2,000-fold selectivity in a panel of 21 serine proteases.
  • Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action.
  • Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.

Catalog No. 50-003-45890


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